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KMID : 0359320030430040667
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Korean Journal of Veterinary Research
2003 Volume.43 No. 4 p.667 ~ p.675
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The Safety of Brucella abortus strain RB51 in pregnant cattle
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김종만/Kim, Jong-man
우승룡/이지연/정석찬/진영화/김재훈/권창희/Woo, Sung-ryong/Lee, Ji-youn/Jung, Suk-chan/Jean, Young-hwa/Kim, Jae-hoon/Kweon, Chang-hee
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Abstract
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The safety of Brucella abortus strain RB51(SRB51) was investigated in dairy cows and Korean native cattle of 4-7th month of gestation. From experimentally inoculated cattle, 18 of 25 (72.0％) dairy cows, and 3 of 10 (30.0％) Korean native cattle were aborted or delivered premature fetus. There were no significant differences in the incidence of abortion depending on the inoculation route (intramuscular and subcutaneous) and dosages (1×10^(9), 2.8×10^(9), and 4.0×10^(9) CFU). The antibodies to the SRB51 were measured by a dot blot enzyme-linked immunosorbent assay. The highest titers to SRB51 were detected between 5∼7 weeks after inoculation and the specific antibody could be detected up to 28 weeks after inoculation. The SRB51 was isolated from amnio-allantoic fluid, bronchial lymph node, mammary gland, and supramammary lymph node in 5 of 25 dairy cows during 4 weeks after either abortion or delivery. Although SRB51 was isolated from 4 of 24 aborted fetus or normally delivered calves at parturition time, it was not isolated during 4 weeks afterward. Eleven of twentyfive dairy cows showed the endometritis and/or necrosis until 6 weeks after delivery, no lesions were ween at 8 weeks after delivery and uterus from control dairy cows. The results of present study revealed that SRB51 might induce the clinical signs of brucellosis in the pregnant cattle at 4∼7th month of gestation.
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